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1.CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org)
518 points by gmays 6 hours ago | hide | 137 comments
2.I Am Not a Reverse Centaur (miguelgrinberg.com)
190 points by ibobev 3 hours ago | hide | 132 comments
3.Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org)
29 points by DASD 1 hour ago | hide | 7 comments
4.How to setup a local coding agent on macOS (ikyle.me)
142 points by kkm 3 hours ago | hide | 48 comments
5.Malware developers added nuclear and biological weapons text to to their spyware (twitter.com/jsrailton)
197 points by marc__1 5 hours ago | hide | 134 comments
6.Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io)
122 points by iweczek 4 hours ago | hide | 51 comments
7.Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work)
27 points by arcb 4 hours ago | hide | 9 comments
8."Don't You Just Upload It to ChatGPT?" (correresmidestino.com)
178 points by speckx 3 hours ago | hide | 149 comments
9.Slightly reducing the sloppiness of AI generated front end (envs.net)
138 points by FergusArgyll 6 hours ago | hide | 97 comments
10.Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org)
86 points by ibobev 5 hours ago | hide | 50 comments
11.A PDF that changes based on how its read (sgaud.com)
96 points by SarthakGaud 4 hours ago | hide | 53 comments
12.Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (yadutaf.fr)
58 points by jtlebigot 6 hours ago | hide | 15 comments
13.Cosmodial Sky Atlas (killedbyapixel.github.io)
20 points by memalign 2 hours ago | hide | 1 comment
14.Mmorpg World of ClaudeCraft, vibe coded with Fable 5 (worldofclaudecraft.com)
4 points by beatthatflight 41 minutes ago | hide | 1 comment
15.There Is Life Before Main in Rust (grack.com)
53 points by mmastrac 4 hours ago | hide | 13 comments
16.A dumpster arrived behind my university's library (yalereview.org)
141 points by mooreds 6 hours ago | hide | 119 comments
17.Maxproof (arxiv.org)
120 points by ilreb 9 hours ago | hide | 10 comments
18.Can I Buy Your KV Cache? (arxiv.org)
4 points by MediaSquirrel 1 hour ago | hide | 2 comments
19.Palantir loses legal challenge against Swiss investigative magazine (ft.com)
15 points by sschueller 36 minutes ago | hide | 2 comments
20.If you are asking for human attention, demonstrate human effort (tombedor.dev)
1433 points by jjfoooo4 22 hours ago | hide | 447 comments
21.Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev)
35 points by datafreak_ 5 hours ago | hide | 12 comments
22.Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com)
8 hours ago | hide
23.WASI 0.3 (bytecodealliance.org)
210 points by mavdol04 7 hours ago | hide | 83 comments
24.A Call to Action: Stop the FCC's KYC Regime (lopp.net)
292 points by FergusArgyll 6 hours ago | hide | 191 comments
25.Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org)
72 points by bookofjoe 4 hours ago | hide | 56 comments
26.You can power on a Mac remotely (jeffgeerling.com)
27 points by speckx 5 hours ago | hide | 13 comments
27.Looking Forward to Postgres 19: It's About Time (pgedge.com)
110 points by xngbuilds 4 hours ago | hide | 32 comments
28.Most Beautiful Will Ever Made (1936) (natlib.govt.nz)
9 points by cf100clunk 3 hours ago | hide | discuss
29.Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org)
53 points by _____k 8 hours ago | hide | 6 comments
30.A jacket that harvests drinking water from the air (utexas.edu)
154 points by ilreb 21 hours ago | hide | 96 comments

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